VARIABILITY AND RESISTANCE MUTATIONS IN THE HEPATITIS C VIRUS NS3 PROTEASE IN PATIENTS NOT TREATED WITH PROTEASE INHIBITORS

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months.However, the current treatment is only effective in m02n3ll/a 50% of patients infected with HCV genotype 1, the most prevalent

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Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine

Depression is a debilitating mental disease, characterized by persistent low mood and anhedonia.Stress represents a major environmental risk factor for wetseat car seat covers depression; the complex interaction of stress with genetic factors results in different individual vulnerability or resilience to the disorder.Dysfunctions of the glutamate s

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ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis

Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types.Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative cancer therapies may be wuh722222ale6l4 available.Checkpoint inhibitor induced colitis (ICI-colitis)

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Evaluation of clinical, laboratory and electrophoretic profile to determine of the prognosis of hospitalized dogs

There are several diseases that can affect pets.Recognize the infirm at risk of death would allow early medical interventions and the establishment of different monitoring protocols, increasing survival.The objective of this work was to analyze the potential for prognostic markers of clinical and laboratory accessible variables in 185 hospitalized

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Beach erosion and nest site selection by the leatherback sea turtle Dermochelys coriacea (Testudines: Dermochelyidae) and implications for management practices at Playa Gandoca, Costa Rica

Leatherback sea turtles (Dermochelys coriacea) nest on dynamic, erosion-prone beaches.Erosive processes and resulting nest loss have long been presumed to be a hindrance to clutch survival.In order to better understand how leatherbacks cope with unstable nesting beaches, I m02n3ll/a investigated the role of beach erosion in leatherback nest site se

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