Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months.However, the current treatment is only effective in m02n3ll/a 50% of patients infected with HCV genotype 1, the most prevalent